THE BIG UNLOCK

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Paddy Padmanabhan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

paddy Hosted by Paddy Padmanabhan

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

Hosted by

Rohit Mahajan Ritu M. Uberoy

Continued by an industry veteran

Rohit Mahajan

Started by a legend

Paddy Padmanabhan

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders  • Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends
• Featuring C-suite Leaders 
• Insights on Digital Health Innovation
• Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

• Stay Updated on Healthcare’s Digital Transformation Trends
• Featuring C-suite Leaders
• Insights on Digital Health Innovation
• Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

Hosted by Rohit Mahajan

Latest Episode

The Big Unlock
The Big Unlock

THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.

Episode 222 – AI is Moving Drug Discovery From Prediction to Generation
byRohit Mahajan & Ritu M. Uberoy

The Big Unlock · Alex Zhavoronkov, Founder, CEO and CBO, Insilico Medicine

In this episode, Alex Zhavoronkov, Founder, CEO and CBO of Insilico Medicine, explores how generative AI is reshaping drug discovery and opening new possibilities in longevity research. He explains how AI can move pharmaceutical R&D from searching for promising molecules toward generating molecules with desired properties, while orchestrating specialized models and agents across the drug development lifecycle. Insilico combines AI models across biology, chemistry, and clinical development to move from target identification to drug candidates faster, with multiple programs now in clinical trials.

Alex argues that AI can dramatically expand the number of experiments researchers can conduct, but the complexity of biology means failure remains inevitable and real-world validation is essential. He discusses the industry’s shift from predictive AI to generative and agentic systems capable of orchestrating thousands of drug discovery tasks, while emphasizing the importance of rigorous validation.

Alex believes the strongest competitive advantages will come from proprietary drugs, scientific infrastructure, capital, and the ability to turn ideas into validated products. He cautions against AI hype and emphasizes benchmarking, peer-reviewed evidence, and clinical results. His ultimate ambition is to use AI-driven drug discovery to extend human lifespan and give people more years of life. Take a listen.

This guest appearance was facilitated through conversations initiated at Ai4 2026.

allseason
date-post

All Episodes

Episode 222 – AI is Moving Drug Discovery From Prediction to Generation

Episode 220 – Cloud and AI Are Reshaping Healthcare Transformation

Episode 219 – Health Literacy is Key to Better Patient Outcomes

Episode 218 – Using Multimodal Foundations and Ambient AI to Scale Clinical Impact

Episode 217 – Building Trust in the Next Generation of Healthcare AI

Episode 216 – The Future of Healthcare Lies in Connected, Evidence-Based Systems

Episode 215 – Bridging Pharma and Startups to Scale Digital Health Innovation

About the Hosts

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has completed executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy is a healthcare AI strategist, technology executive, educator, and author dedicated to advancing the responsible adoption of Artificial Intelligence across healthcare delivery, digital health, and life sciences. With more than twenty-five years of leadership experience spanning the United States and India, she is recognized for helping healthcare organizations move beyond experimentation to achieve scalable clinical, operational, and business transformation through AI.

She leads AI innovation initiatives, including the AI Center of Excellence at BigRio, where she works with health systems, healthcare technology companies, and life sciences organizations to operationalize Generative and Agentic AI solutions responsibly. Her work focuses on aligning AI innovation with clinical workflows, governance frameworks, workforce readiness, and patient trust—ensuring technology augments human judgment in high-consequence healthcare environments.

Ritu is the co-author of Generative AI: Unlocking the Next Chapter in Healthcare, a practical guide for healthcare executives navigating enterprise AI adoption. She also hosts The Big Unlock podcast, engaging global healthcare leaders on AI transformation and digital innovation. An active educator and speaker, she conducts executive workshops and participates in global forums like HIMSS, ViVE, Women in Tech, AI-Powered Women, RAISE, and more, shaping the future of AI-driven healthcare. Ritu holds advanced degrees in Computer Science and completed specialized AI programs at Harvard and MIT.

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has completed executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy is a healthcare AI strategist, technology executive, educator, and author dedicated to advancing the responsible adoption of Artificial Intelligence across healthcare delivery, digital health, and life sciences. With more than twenty-five years of leadership experience spanning the United States and India, she is recognized for helping healthcare organizations move beyond experimentation to achieve scalable clinical, operational, and business transformation through AI.

She leads AI innovation initiatives, including the AI Center of Excellence at BigRio, where she works with health systems, healthcare technology companies, and life sciences organizations to operationalize Generative and Agentic AI solutions responsibly. Her work focuses on aligning AI innovation with clinical workflows, governance frameworks, workforce readiness, and patient trust—ensuring technology augments human judgment in high-consequence healthcare environments.

Ritu is the co-author of Generative AI: Unlocking the Next Chapter in Healthcare, a practical guide for healthcare executives navigating enterprise AI adoption. She also hosts The Big Unlock podcast, engaging global healthcare leaders on AI transformation and digital innovation. An active educator and speaker, she conducts executive workshops and participates in global forums like HIMSS, ViVE, Women in Tech, AI-Powered Women, RAISE, and more, shaping the future of AI-driven healthcare. Ritu holds advanced degrees in Computer Science and completed specialized AI programs at Harvard and MIT.

About the Legend

Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor &  Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.