THE BIG UNLOCK

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Paddy Padmanabhan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

paddy Hosted by Paddy Padmanabhan

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

Hosted by

Rohit Mahajan Ritu M. Uberoy

Continued by an industry veteran

Rohit Mahajan

Started by a legend

Paddy Padmanabhan

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders  • Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends
• Featuring C-suite Leaders 
• Insights on Digital Health Innovation
• Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Decoding Healthcare Transformation Through AI

• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders 
• Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

Season 6 Recap

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

• Stay Updated on Healthcare’s Digital Transformation Trends
• Featuring C-suite Leaders
• Insights on Digital Health Innovation
• Explore Emerging Healthcare Technologies

Hosted by

Rohit Mahajan

CEO & Managing Partner
Damo and BigRio

Ritu M. Uberoy

Managing Partner
Damo and BigRio

LISTEN TO
THE BIG UNLOCK PODCAST

Healthcare Digital Transformation Podcast

Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.

Hosted by Rohit Mahajan

Latest Episode

The Big Unlock
The Big Unlock

THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.

Episode 220 – Cloud and AI Are Reshaping Healthcare Transformation
byRohit Mahajan & Ritu M. Uberoy

The Big Unlock · Dr. Angela Shippy, Senior Physician Executive and Clinical Innovation Lead, Amazon Web Services (AWS)

In this episode, Dr. Angela Shippy, Senior Physician Executive and Clinical Innovation Lead at Amazon Web Services (AWS), shares how cloud and AI are reshaping healthcare by helping organizations move from experimentation to enterprise-scale transformation. She explains that successful AI adoption requires more than powerful models – it demands secure cloud infrastructure, responsible governance, workforce upskilling, and trusted partnerships.

Dr. Shippy explains how leading health systems are moving beyond isolated AI pilots by solving well-defined organizational and clinical challenges first. Through purpose-built services like Amazon Connect Health, institutions are streamlining patient engagement, reducing administrative burden, and improving access to care. From antimicrobial resistance surveillance to genomics research and health equity programs, she illustrates how cloud-based platforms are helping healthcare organizations generate insights faster and improve patient outcomes at scale.

Dr. Shippy believes that scaling enterprise AI requires upskilling healthcare workforces, establishing strong security guardrails, and embracing agentic workflows. She envisions a future driven by multimodal AI, ambient listening, and automated task execution that accelerates drug discovery, reduces burnout, and enables clinicians to focus on direct patient care. Dr. Shippy encourages health systems to start small, think big, and never lose sight of improving patient and workforce experiences. She believes agentic technologies will augment clinicians, accelerate innovation, and help build a more connected, efficient, and patient-centered healthcare ecosystem. Take a listen.

This guest appearance was facilitated through conversations initiated at ViVE.

allseason
date-post

All Episodes

Episode 220 – Cloud and AI Are Reshaping Healthcare Transformation

Episode 219 – Health Literacy is Key to Better Patient Outcomes

Episode 218 – Using Multimodal Foundations and Ambient AI to Scale Clinical Impact

Episode 217 – Building Trust in the Next Generation of Healthcare AI

Episode 216 – The Future of Healthcare Lies in Connected, Evidence-Based Systems

Episode 215 – Bridging Pharma and Startups to Scale Digital Health Innovation

Episode 214 – The Future of Medicine Requires Trust, Technology, and Leadership

Episode 213 – Innovation is About Solving Problems, Not Chasing Technology

About the Hosts

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has completed executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy is a healthcare AI strategist, technology executive, educator, and author dedicated to advancing the responsible adoption of Artificial Intelligence across healthcare delivery, digital health, and life sciences. With more than twenty-five years of leadership experience spanning the United States and India, she is recognized for helping healthcare organizations move beyond experimentation to achieve scalable clinical, operational, and business transformation through AI.

She leads AI innovation initiatives, including the AI Center of Excellence at BigRio, where she works with health systems, healthcare technology companies, and life sciences organizations to operationalize Generative and Agentic AI solutions responsibly. Her work focuses on aligning AI innovation with clinical workflows, governance frameworks, workforce readiness, and patient trust—ensuring technology augments human judgment in high-consequence healthcare environments.

Ritu is the co-author of Generative AI: Unlocking the Next Chapter in Healthcare, a practical guide for healthcare executives navigating enterprise AI adoption. She also hosts The Big Unlock podcast, engaging global healthcare leaders on AI transformation and digital innovation. An active educator and speaker, she conducts executive workshops and participates in global forums like HIMSS, ViVE, Women in Tech, AI-Powered Women, RAISE, and more, shaping the future of AI-driven healthcare. Ritu holds advanced degrees in Computer Science and completed specialized AI programs at Harvard and MIT.

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has completed executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy is a healthcare AI strategist, technology executive, educator, and author dedicated to advancing the responsible adoption of Artificial Intelligence across healthcare delivery, digital health, and life sciences. With more than twenty-five years of leadership experience spanning the United States and India, she is recognized for helping healthcare organizations move beyond experimentation to achieve scalable clinical, operational, and business transformation through AI.

She leads AI innovation initiatives, including the AI Center of Excellence at BigRio, where she works with health systems, healthcare technology companies, and life sciences organizations to operationalize Generative and Agentic AI solutions responsibly. Her work focuses on aligning AI innovation with clinical workflows, governance frameworks, workforce readiness, and patient trust—ensuring technology augments human judgment in high-consequence healthcare environments.

Ritu is the co-author of Generative AI: Unlocking the Next Chapter in Healthcare, a practical guide for healthcare executives navigating enterprise AI adoption. She also hosts The Big Unlock podcast, engaging global healthcare leaders on AI transformation and digital innovation. An active educator and speaker, she conducts executive workshops and participates in global forums like HIMSS, ViVE, Women in Tech, AI-Powered Women, RAISE, and more, shaping the future of AI-driven healthcare. Ritu holds advanced degrees in Computer Science and completed specialized AI programs at Harvard and MIT.

About the Legend

Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor &  Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.