Kicking Off HLTH USA 2025: Big Ideas, Bold Voices, and Real Momentum – Day 1

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Rohit Mahajan

Co-Host of The Big Unlock Podcast

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It was an energizing start to HLTH USA 2025 here in Las Vegas! As host of The Big Unlock podcast and a media attendee, I spent the day immersed in conversations, sessions, and stories that set the tone for a transformative week ahead in healthcare innovation.

  • The event opened with a full slate of partner programs—from Value-Based Care to Pharma and Clinician tracks—each tackling the urgent need for integration, data transparency, and sustainable value creation in care delivery.
  • The opening keynote and welcome session brought palpable momentum. Mark Cuban’s fiery take on drug pricing and transparency reminded everyone that the business of healthcare must evolve to serve patients better.
  • AI was everywhere—not as a buzzword, but as a practical tool already reshaping clinical workflows, patient access, and decision-making. The message was clear: AI-native healthcare isn’t coming; it’s already here.

The networking floor buzzed with startups, investors, and providers exploring collaborations that could define the next generation of digital health solutions.

Some takeaways

  • Transparency and affordability are fast becoming the moral currency of healthcare innovation.
  • AI adoption has crossed the experimentation phase—the focus now is on scaling responsibly and proving measurable outcomes.
  • Ecosystem collaboration is the new competitive advantage; silos are dissolving as employers, payers, and tech companies seek shared wins.
  • And perhaps most importantly—the best insights often came from hallway conversations and spontaneous exchanges, not just the mainstage.

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The Healthcare Digital Transformation Leader

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The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.