THE BIG UNLOCK
Healthcare Digital Transformation Podcast
Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Paddy Padmanabhan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.
Hosted by Paddy Padmanabhan
LISTEN TO
THE BIG UNLOCK PODCAST
Healthcare Digital Transformation Podcast
Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.
Hosted by
Rohit Mahajan
Ritu M. Uberoy

Rohit Mahajan

Paddy Padmanabhan
Decoding Healthcare Transformation Through AI
• Stay Updated on Healthcare’s Digital Transformation Trends • Featuring C-suite Leaders • Insights on Digital Health Innovation • Explore Emerging Healthcare Technologies
Hosted by

CEO & Managing Partner
Damo and BigRio

Managing Partner
Damo and BigRio
Healthcare Digital Transformation Podcast
• Stay Updated on Healthcare’s Digital Transformation Trends
• Featuring C-suite Leaders
• Insights on Digital Health Innovation
• Explore Emerging Healthcare Technologies
Hosted by

CEO & Managing Partner
Damo and BigRio

Managing Partner
Damo and BigRio
LISTEN TO
THE BIG UNLOCK PODCAST
Healthcare Digital Transformation Podcast
Stay up to date on current trends in healthcare’s digital transformation. Featuring C-suite executives from the healthcare and technology sectors, podcast host Rohit Mahajan discusses how they are driving digital health innovation and leveraging emerging healthcare technologies to create improved patient experiences.
Hosted by Rohit Mahajan
The Big Unlock · Gregory Goldmacher, M.D., Associate Vice President in Clinical Research, and Head of Clinical Imaging & Pathology, Merck Research Laboratories
In this episode, Dr. Greg Goldmacher, Associate VP of Clinical Research at Merck, known as MSD outside of the United States and Canada, explains how AI is transforming imaging, clinical trials, and early-stage drug development. Greg describes endpoints as the core of every clinical trial, since they determine whether a therapy is safe or effective. He notes that AI is not new to imaging and aligns well with pattern recognition, yet its real value lies in identifying details that humans often miss.
Greg stresses that drug development still depends on huge volumes of data spread across legacy systems. Without strong data standardization, AI cannot deliver reliable results. He also points to the FDA’s evolving guidance on AI and emphasizes the need for rigorous validation before using AI-derived measurements for regulatory decisions.
Greg highlights the opportunity to improve efficiency, reduce human burden, and generate more consistent insights. With thoughtful adoption, AI can support better decisions in clinical development and improve outcomes for patients. Take a listen.

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.
Rohit is skilled in business and IT strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a Wharton School Fellow and a graduate from the Harvard Business School.
Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has completed executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed the Global Healthcare Leaders Program from Harvard Medical School.
Ritu M. Uberoy has over twenty-five years of experience in the software and information technology industry in the United States and in India. She established Saviance Technologies in India and has been involved in the delivery of several successful software projects and products to clients in various industry segments.
Ritu completed AI for Health Care: Concepts and Applications from the Harvard T.H. Chan School of Public Health and Applied Generative AI for Digital Transformation from MIT Professional Education. She has successfully taught Gen AI concepts in a classroom setting in Houston and in workshop settings to C-Suite leaders in Boston and Cleveland. She attended HIMSS in March 2024 at Orlando and the Imagination in Action AI Summit at MIT in April 2024. She is also responsible for the GenAI Center of Excellence at BigRio and DigiMTM Digital Maturity Model and Assessment at Damo.
Ritu earned her Bachelor’s degree in Computer Science from Delhi Institute of Technology (now NSIT) and a Master’s degree in Computer Science from Santa Clara University in California. She has participated in the Fellow’s program at The Wharton School, University of Pennsylvania.
Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor & Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.
Stay informed on the latest in digital health innovation and digital transformation