Month: September 2025

AI Innovation Across Healthcare and Pharma

Season 6: Episode #182

Podcast with Thomas J. Fuchs,
Chief AI Officer, Eli Lilly and Company

AI Innovation Across Healthcare and Pharma

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In this episode, Thomas Fuchs, Chief AI Officer at Eli Lilly, shares his journey from early machine learning research to spearheading transformative AI initiatives across the pharmaceutical value chain. Lilly is running over a thousand AI projects—from drug discovery and development to manufacturing and commercial operations—leveraging innovations like language models for chatbots, computer vision for quality control, and biomarker development.

Thomas emphasizes trust, transparency, and collaboration as critical to AI adoption, supported by AI certification programs for all Lilly technology employees, as well as AI education resources being made available for everyone at Lilly. He also highlights the company’s unique “lab-in-the-loop” setups that generate synthetic data to accelerate innovation.

Thomas shares real-world successes, including AI-assisted drug discovery and intelligent chatbots, and how AI is building confidence across the organization. With robust data infrastructure and scalable strategies for synthesizing large datasets, Lilly is driving rapid innovation. Thomas predicts faster drug design, broader access to medicines, and continuous education as defining trends for AI in healthcare. Take a listen.

Video Podcast and Extracts

About Our Guest

Thomas J. Fuchs, Dr.sc., joined Eli Lilly and Company as its first chief AI officer in 2024. In this role, Fuchs provides vision, strategic direction and overall leadership of AI initiatives across Lilly, including drug discovery, clinical trials, manufacturing, commercial activities and internal functions. He also identifies, builds and manages AI and machine learning solutions to help Lilly provide medicines to patients around the world.

Before Lilly, Fuchs was dean and inaugural department chair for AI and Human Health at Mount Sinai, director of the Hasso Plattner Institute for Digital Health at Mount Sinai, and endowed Barbara T. Murphy professor for AI and computational pathology at the Icahn School of Medicine at Mount Sinai. Prior, Fuchs held positions at Memorial Sloan Kettering Cancer Center, NASA's Jet Propulsion Laboratory and the California Institute of Technology. He also founded three companies, including Paige AI. Fuchs holds a doctoral degree in machine learning from ETH Zurich and a master’s degree in technical mathematics from Graz Technical University in Austria.


Q: Hi, Dr. Michael Docktor, welcome to our Big Unlock podcast. We are really happy to have you as a guest on our show. Uh, it’s on our sixth season now, and, uh, we are looking forward to this conversation. I’m sure we’ll have a very engaging and interesting conversation about dog health, about healthcare in general, and the new trends about AI and all the buzzwords that people want to hear. Welcome to our show — we’d like to start with introductions. Happy to have you give your introduction. Thank you.

Michael: Yeah, thank you so much for having me. Yeah, I’m Michael Docktor, co-founder and CEO of Dock Health. I’m an ologist by trade. I am now on this, uh, healthcare venture outside of Boston Children’s Hospital where I started my GI career.

I was a busy clinician working on the clinical side as well as in innovation and informatics, and found that we had wonderful tools in the world outside of healthcare and struggled with my own challenges around managing all the tasks that are part of patient care. I found that I was using task management and project management tools that were not built for healthcare.

I scratched my head and wondered why we don’t have these things for healthcare. That was a journey. We started just over five years ago. We spun out Dock Health from Boston Children’s, and we’ve been on a very exciting journey in the world outside the academic walls since then.

It’s been fun. I’m excited to talk to you more about, uh, what we’re doing.

Q Great. That’s a great introduction. Thank you for letting our listeners know. We usually like to start with how you came into healthcare because everyone has an interesting story about what inspired them to become a physician.

For you, it’s particularly interesting because you’ve created this interface between design, technology, and healthcare — and you went beyond just visualizing what you wanted to do or asking why somebody doesn’t fix it, to actually building it yourself. I’d love to hear more about how you came into medicine and then into technology.

Michael: I could probably spend the entire podcast on this question. Obviously, my last name is Doctor, so there was some planting occurring there, and there’s something to be said for that.

One of my earliest memories was wanting to grow up to be a doctor. My younger sister had some GI issues when we were young, and I became very close with her gastroenterologist. I followed her on her journey and, unbeknownst to me, ended up following one of my mentors and was inspired to do the work for other children the way my sister was cared for. That was the initial inspiration.

You mentioned design. That’s interesting because my mother is an interior designer, my father is a dentist who specialized in aesthetics, and design — how things look, feel, and work — has always been part of my DNA. It was an amazing journey to go from being a traditional doctor in pediatric gastroenterology to discovering the importance of user experience and user interface.

Then the iPhone came out, then the iPad, and that really started me on my journey of exploring app development and software, and wondering why we didn’t use these wonderful devices in our pockets the way we should. That journey started more than 10 years ago and has led me to this perfect intersection of healthcare, design, and informatics, creating better experiences for patients and providers.

There’s a lot to unpack there, but people ask me if I would do it differently if I had the chance to do it all over — and absolutely not. I’m doing exactly what I want to be doing right now.

Q: Thank you for sharing that. That gives us so much perspective into how you came into this field, the influence of your parents, and how everyone around you inspired you to do this. That’s really interesting.

That leads us into how you built Dock Health. Tell us some examples of how you saw this becoming transformational in actual implementations with clients. When you built the tool, did you visualize exactly what it would do? Did it go beyond what you thought it would achieve in a healthcare setting? We’d love to hear more about that.

Michael: We’re far beyond where I ever thought we’d be when we first started this journey. That’s the exciting part. Fundamentally, we have such an administrative and operational challenge in healthcare. I saw it firsthand as a busy clinician struggling to manage all the clinically adjacent work that had to be done for my patients.

For example, I might have a patient with Crohn’s disease who needs to go to an infusion center. There are all these downstream tasks and administrative steps that need to be done by a team of people. We didn’t have assistants to do that, and the electronic health record wasn’t built for it.

A quarter of the $5 trillion spent in healthcare goes to administrative and operational challenges, and there really are no tools built for that. We rely on paper checklists, email, faxes, and spreadsheets to manage all the work happening outside the electronic health record.

For me, the realization was that I was using wonderful project management and task management tools to run software projects in my innovation and informatics roles—and yet nothing like that existed in healthcare. Patients, in many ways, are projects. There are tasks that form the essence of care, and they need to be tackled, managed, and collaborated on, with visibility and accountability across teams. That didn’t exist.

What we are now doing is serving as that productivity platform for healthcare, one that sits alongside the electronic health record in synergy, helping manage all the administrative and operational tasks of patient care in ways the EHR wasn’t designed for.

Some examples would be managing patient intake and all the processes associated with it. Referrals, inbound and outbound, with all the paperwork, eligibility checks, and faxes—those workflows are still incredibly manual. Referrals are a great example: 80% of referrals that come into major academic medical centers are still arriving by fax, despite the fact that they’re using Epic, a wonderful electronic health record.

These processes are still incredibly laborious, take too long, and are inefficient. Patient care suffers along the way. There’s a gigantic bottleneck around the administrative and operational work that moves patients through their journeys, and that’s what we’re focused on fixing.

Q: This is what we hear from a lot of our clients and other CIOs and C-suite leaders who come to our podcast—that this is one major problem with healthcare. It’s siloed, and the processes are really stuck in the dark ages.

We were talking to somebody from Athena, and they said they had an 800-person offshore center in India just to screen faxes. When a fax came in, one person looked at it to see if it was a pizza order or a referral. It sounds unbelievable in this day and age, but that’s how it works. I’m amazed to hear this from you as well. It’s remarkable.

Michael: Yeah. In fact, Athena is a partner of ours, and we’re working on referral management. It’s an incredibly antiquated process where everyone loses visibility. The amount of manual labor required to process these things is shocking in this day and age, when they can be handled through process automation, AI, and agents.

Q: Exactly. You’re talking about agentic, we’re talking about voice agents, and yet we’re still dealing with faxes. That’s really interesting to know.

Michael: There is reason to be hopeful. Healthcare is always many decades behind, but the adoption of AI is progressing more rapidly than I’ve seen any technology adopted in healthcare. There’s reason for hope.

Q: That leads into my next question, but before we get there, you mentioned Dock Health as a productivity platform. That’s what it does for doctors, clinicians, and patients. But when we talk to our doctors, clients, and health systems, the one word that always comes up is complexity. They deal with so many different systems and have to learn something new each time.

Where does Dock Health fit in? Is it another system they have to manage, or does it help reduce that burden?

Michael: Yeah, it’s all about reducing the burden and improving the user experience. That’s been fundamental to our belief system since the founding of the company.

First and foremost, we’re trying to become the productivity platform and the hub that handles the administrative and operational work. Instead of being “another system,” we’re often replacing spreadsheets, paper checklists, emails, and faxes—the ways we’ve traditionally managed the 50% or more of administrative and operational tasks required for patient care.

The EHR is great for clinical work, billing, prescribing, and scheduling, but so much happens downstream that isn’t covered. I’d argue we are creating the hub for that. Just as the EHR is the clinical hub, Dock Health serves as the operational hub. Together, it’s really one plus one equals three.

We’re also aiming to be much more consumer-like in our approach. Our tool can onboard a customer in 30 minutes. We offer a free trial, and for small organizations that want to get up and running, they can start using it right away—just like downloading an app. It’s lightweight, highly configurable for end users, and designed with a strong focus on user experience.

The real challenge is that clinicians don’t want another tool. They’re busy and need to spend their time in the EHR. Our core users are often the super users: front office staff, back office teams, operational leaders, and administrative staff who leverage our tool every day.

The important piece is that we connect to the electronic health record and provide visibility for clinicians. If they’re interested, they can see where a patient is in their journey or where a process stands, but they don’t have to be in our system all day, checking tasks or learning another workflow.

The intent is to provide that operational hub for administrative and support staff—the essential members of the care team—while clinicians continue their work in the EHR and often drive tasks into our system through their orders and actions there.

Q: Is the integration with the EHRs native, like with Epic, Cerner, and the big ones?

Michael: Yeah. We’re on the marketplace with a number of the top EHRs, including Epic and Cerner. We’re also working with Mayo Clinic, their Mayo Clinic Platform, and their Deploy platform.

The other thing I’d mention is that many organizations use our tools without being integrated with the electronic health record. That’s often because they’re smaller practices—mental health, concierge care, or primary care—that simply need a hub to handle administrative and operational work and collaborate as a team.

We spend a lot of time helping organizations define their processes, and those processes can then live in Dock, where they can be collaborated on and turned into operational best practices. That’s something that often doesn’t happen in traditional healthcare organizations, and our tool is valuable even when it’s not connected to an EHR.

Of course, the real value comes when we integrate with systems—EHRs, CRMs, patient engagement tools—and serve as the hub while automating as many tasks as possible. That’s when the flywheel starts turning, and organizations begin to feel the benefits of automation and work reduction. It ultimately moves the needle in a measurable way.

Q: So, you’re saying if there’s an integration with the EHR, then it’s end-to-end and people can see a complete view of what’s happening. But even without the EHR, because it helps with workflow management, it’s valuable for practices?

Michael: It’s just like every other industry. They have Asana, JIRA, Trello—all these tools where a lot of the real work gets done. That provides value in itself by giving a clear view into where the patient is in their journey and what process they’re following.

When we integrate with an EHR or other systems, we can then automate those workflows. For example, when a fax comes in, we can launch a workflow for a new patient referral. When a lab order is placed, we can launch a workflow for follow-up. Or when a patient has a procedure, we can launch a process for their downstream follow-up.

Q: That leads into the next question, which is your learning journey with AI. What advice do you have for our listeners about where AI is headed? And with voice agents and agentic tech being buzzwords, where do you see Dock Health going? Are you also looking at implementing voice agents?

Michael: AI is incredibly exciting. I’ve put it out there that we’re an AI-first company. We’ve been thinking about this for a while, and we already have what we call Dock Intelligence in production with customers. We started with the basics, using foundational models and generative AI to process large troves of data.

Now, we can summarize all the work being done for a patient and create a snapshot for the end user—showing all tasks, workflows, patient context, and even clinical context if available. That gives a quick overview of what’s happening. Users can edit that snapshot if needed, or generate a note that writes back to the EHR to keep the operational and clinical record in sync.

That’s the first step in our AI journey. From there, we realized tasks bundle into workflows, workflows can be automated, and now we’re starting to farm out those tasks to agents and AI. For example, a voice agent could follow up with a patient to confirm a referral or review lab results. We’re actively pursuing that, as well as leveraging AI to extract data from faxes to automate referral processes.

AI is the big unlock. In the next three to five years, I believe most administrative and operational tasks will be handled by automation and AI agents orchestrating together. These agents need rails to run on and structure to guide them, and end users must remain in the loop to provide oversight and visibility. But the lion’s share of this work will be handled by agents—and we’re building that future right now.

Q: Are you aligning specifically with any particular LLM or provider, or are you going to be completely agnostic?

Michael: I’d like to think we’ll be agnostic. We’re doing plenty of building on some of the foundational models ourselves, and we’re partnering where we can with great tools. For example, with voice agents, we’re not necessarily building them ourselves—there are excellent options out there. What we are doing is building our own homegrown AI agents that can manage processes and facilitate handoffs from task to task.

Our approach has always been to recognize that there’s a wonderful ecosystem out there. We want to be the hub that connects to the best-of-breed systems—whether that’s Epic as an EHR, Salesforce as a CRM, or other tools we can leverage to create a healthy ecosystem. That’s what we’re pursuing.

Q: I wanted to ask a question about that because with the LLMs, one of the main problems is the hallucinations or the repeatability or the trust factor there. So I saw that Dock is HITRUST certified. So, I just wanted to ask, what are your views on that? Because in terms of using generative AI when we talk to our clients, uh, for implementations on LLMs, or they’re more comfortable certainly with the administrative tasks, but even with the administrative tasks there’s always the question of what are the guardrails you put around that and how do you make sure that the results that you are seeing or you are displaying on Doc Health, you know, stay within that, those bounds of accuracy. Whathat are your thoughts around that?

Michael: AI is incredibly exciting—it’s moving at the speed of light, and everyone wants to benefit from it. I do think administrative and operational areas of healthcare are lower-hanging fruit and far less risky. We’re not yet in a place where we can reliably use AI for absolute clinical decision support and autonomy, though I believe we’ll get there in the not-too-distant future.

For now, the clunky and manual administrative work is ripe for AI. Still, we need to be mindful of potential hallucinations. In our experience so far, we haven’t seen issues, but we’ve put safeguards in place. That means keeping a human in the loop to ensure outputs are appropriate and relevant. We also give users the ability to edit results before they’re sent—whether it’s a summary being emailed to a colleague or written back into the EHR as a clinical note.

It’s essential to show your work. If we’re pulling data from various sources, we show those sources. We keep users in the loop, give them control to review and edit, and maintain tight feedback loops to catch and address anything off.

So far, even foundational LLMs have been surprisingly strong in our relatively narrow use cases. The real challenges will come as we move toward higher-risk clinical decision support—but I’m confident we’ll get there quickly.

Q: It’s interesting you mentioned humans in the loop and the fact that people can review or edit what’s being generated. But with agents, one of the key defining characteristics is autonomy—they can make API calls, send emails, even browse the web to find and act on information. How do you think about that level of control being handed over?

Michael: I think it’s all about balance. The value of task automation and workflow automation is clear. For us, one of our strengths is providing a user interface where the end user can actually see where a process is in its journey.

We’re working on features like showing confidence levels or confidence intervals for data extracted—for example, from a fax. That way, we not only show our work but also give transparency into how accurate that extraction might be. Using our interface, which breaks workflows into tasks, we can show exactly where a process stands. If we believe human involvement is needed, we assign a task and call someone in to review.

Even in the agentic future—which is already upon us and actively being built and tested—we see ways to keep humans in the loop. Operating entirely in a vacuum is risky. Part of my mantra, coming from clinical practice, is that I lacked visibility and accountability in the work being done on behalf of my patients, lost in a black hole of faxes and emails. It’s important to show where the patient is in their journey, where the process stands, whether an agent is handling it or automation is moving data between systems. Giving people visibility and the ability to drill down is critical.

Q: That’s an interesting viewpoint. You mentioned the front and back office and clinicians, but I didn’t realize patients might also have visibility into the system.

Michael: That’s certainly the vision for the future. Right now, our solution focuses on creating visibility and accountability for the care team—clinical and operational staff. But ultimately, the patient is part of the care team too. I would love to see a future where patients are assigned tasks and the rest of the care team has visibility into their progress. I think that’s inevitable. For now, we’re focused on giving the traditional care team the tools they need, but over time, I see patients and their home-based care team being part of that ecosystem.

Q: So I think we are almost at the end of the podcast. We would like to conclude by asking you what you think, maybe give a horizon of like a year and then maybe a five-year horizon. What do you think the top trends that are going to be in AI, and particularly for you at Dock Health? What are the three things that you are really keeping close tabs on and you feel that it’s going to really impact your product and be very transformational.

Michael: It’s tough to predict because AI is moving so fast. Moore’s Law doesn’t apply anymore—the doubling is happening every few months. Everything right now is AI, and “agentic” is the word of the day. I’ve even heard “ambient agents.” We see our role as orchestrating workflows where agents will carry out the majority of tasks.

When we started Dock Health, I imagined a day when it would be smart enough to handle processes automatically. AI has accelerated that roadmap by five to ten years, and the pace keeps shrinking. I truly believe that in the next five years, when healthcare spending in the U.S. reaches $10 trillion, the $2.2 trillion spent on administrative and operational costs may actually shrink because of operational efficiencies unlocked by AI.

We want to give care teams superpowers. Administrative and operational staff deserve better tools to do their work. Just as ambient scribes are now relieving clinicians from documentation, I believe AI will do the same for the administrative and operational burdens in healthcare. Within three to five years, I expect most of that work will be automated. Humans will still play a role, but much of it will feel like it just happens—almost magically.

If you zoom out five years from now, it will look like magic. But by then it will feel obvious. And that excites me, because at the end of the day, patients, our economy, and the world need more efficient care. The fact that we waste a trillion dollars a year on administrative tasks is shameful. Patients are asked to take on too much, like reminding us about referrals or tracking down lab results. These things happen because we’re human and don’t scale well. But now we have incredible tools at our fingertips, and I believe the next few years will be the most exciting time healthcare has ever experienced.

If we zoom out five years from now, it’s going to look like magic—but by then it will feel obvious. I’m excited for that future because, at the end of the day, patients, our economy, and our world need more efficient care. The fact that we waste a trillion dollars a year on administrative and operational tasks is shameful.

Too much of the burden falls on patients. Physicians and care teams often say, “Call me if you don’t get your referral in a couple of days,” or, as I saw with my own mom recently, patients are left chasing down lab results. These things happen because we’re human and we don’t scale well.

Now, we have incredible tools at our fingertips. That’s why I believe the coming years will be the most exciting time in healthcare that I’ve ever experienced—and likely the most exciting time the world has ever seen. Healthcare is primed for transformation and opportunity.

Q: Thank you for being with us on our podcast. It was a wonderful conversation, and we look forward to sharing your vision for the future with our listeners.

Michael: Thanks so much.

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Subscribe to our podcast series at www.thebigunlock.com and write us at [email protected]  

Disclaimer: This Q&A has been derived from the podcast transcript and has been edited for readability and clarity.

About the host

Paddy is the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor & Francis, Aug 2020), along with Edward W. Marx. Paddy is also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He is the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He is widely published and has a by-lined column in CIO Magazine and other respected industry publications.

About the Hosts

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has previously also worked with IBM and Wipro. He completed his executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy has over twenty-five years of experience in the software and information technology industry in the United States and in India. She established Saviance Technologies in India and has been involved in the delivery of several successful software projects and products to clients in various industry segments.

Ritu completed AI for Health Care: Concepts and Applications from the Harvard T.H. Chan School of Public Health and Applied Generative AI for Digital Transformation from MIT Professional Education. She has successfully taught Gen AI concepts in a classroom setting in Houston and in workshop settings to C-Suite leaders in Boston and Cleveland. She attended HIMSS in March 2024 at Orlando and the Imagination in Action AI Summit at MIT in April 2024. She is also responsible for the GenAI Center of Excellence at BigRio and DigiMTM Digital Maturity Model and Assessment at Damo.

Ritu earned her Bachelor’s degree in Computer Science from Delhi Institute of Technology (now NSIT) and a Master’s degree in Computer Science from Santa Clara University in California. She has participated in the Fellow’s program at The Wharton School, University of Pennsylvania.

About the Host

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has previously also worked with IBM and Wipro. He completed his executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

About the Legend

Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor &  Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.

From Reactive to Proactive Care with AI in Healthcare

From Reactive to Proactive Care with AI in Healthcare

From Reactive to Proactive Care with AI in Healthcare

In a recent episode of The Big Unlock podcast, Dr. Girish N. Nadkarni – Fishberg Professor of Medicine, Chair of the Windreich Department of Artificial Intelligence and Human Health, and Chief AI Officer of the Mount Sinai Health System — offered a clear, pragmatic perspective on how technology can reshape clinical care. Drawing on clinical practice, research, and operational leadership, Dr. Nadkarni emphasized that the real promise of digital health is not novelty for novelty’s sake, but the ability to scale medical knowledge and buy clinicians time to make better decisions.

From Clinician to AI Leader

Dr. Nadkarni’s professional background informs his practical outlook. A trained internist and nephrologist who still spends roughly 25 percent of his time in patient care, he described how his clinical work and academic research intersect in a health system that uniquely integrates its medical school and clinical operations. That integration, he explained, creates a virtuous cycle: clinical problems inspire research questions, and academic breakthroughs can be translated, deployed, and scaled across the system. This operating model gives his perspectives an operational realism that is often missing in more theoretical discussions about AI.

AI as an “Arbitrage of Knowledge for Time”

One of the episode’s most resonant themes was Dr. Nadkarni’s description of AI as an “arbitrage of knowledge for time.” He used concrete examples to unpack this idea. Ambient AI scribes, for instance, transcribe clinical conversations and generate structured notes that clinicians can review and sign. What previously consumed ten minutes per patient for documentation can be reduced to a matter of seconds — Dr. Nadkarni cited a shift from about ten minutes to roughly 30 seconds to finalize notes. That regained time is not trivial: it removes after-hours clerical burden, improves clinician well-being, and returns face-to-face time to patients.

Another application moves care from reactive to proactive. Dr. Nadkarni described a deterioration model deployed in production that predicts patient decline an hour before it happens. That early warning allows teams to intervene — adjusting fluids, antibiotics, or other treatments — potentially averting serious deterioration. Similarly, in the neonatal intensive care unit, vision-based AI systems can continuously monitor infants and flag signs of impending illness well before clinical deterioration. In these cases, the system provides a crucial window of time for lifesaving interventions: that is the practical meaning of arbitraging knowledge for time.

Trust, Scale, and the Double-edged Nature of Technology

Dr. Nadkarni was careful to balance enthusiasm with caution. He stressed that healthcare is a trust-sensitive industry: “trust between a provider and a patient… is paramount.” Scale multiplies both benefits and risks. “If goodness can scale, badness can scale as well,” he warned. A well-intentioned model that contains bias or is applied without contextual safeguards can propagate harm at scale. He used an illustrative example: an algorithm predicting which patients might not show up for clinic appointments could, if misapplied, lead to cancelling appointments for patients who most need care — often the very people experiencing social barriers to access. The right response, he argued, is to address unmet social needs (transport, financial assistance) rather than withdraw services.

To mitigate such risks, Dr. Nadkarni outlined governance mechanisms: an assurance lab to monitor models and a REP (Risk, Ethics, and Policy) committee to evaluate applications. He argued that prototyping and scaling are valid ambitions only if paired with rigor, evidence, and thoughtful governance — a framework that ensures AI systems are safe, effective, responsible, and ethical.

Predictive AI Versus Generative AI: Different Characters, Different Guards

The podcast highlighted the distinction between predictive AI and newer generative models. Predictive models tend to be deterministic and repeatable: the same input yields the same output, which lends itself to reproducible evaluation and monitoring for drift and bias over time. Generative models and large language models, by contrast, are more flexible and non-deterministic; their outputs can vary and require broader evaluation against ethical principles and guardrails.

Dr. Nadkarni described this contrast metaphorically as akin to “left and right sides of the brain” — one logical and structured, the other creative and non-linear. For institutions, the implication is that evaluation and governance strategies must be tailored to the technology class. Both model types require monitoring, but the methods and metrics differ.

Operationalizing AI: Teams, Governance, and Multidimensional ROI

Operational readiness is a recurring theme for leaders trying to move from pilots to scale. Dr. Nadkarni emphasized the importance of cross-functional and multidimensional teams that blend clinical domain expertise with technical capability. Effective AI teams include clinicians or allied professionals who understand the problem, MLOps or AI-ops engineers who build scalable models, research scientists who explore novel approaches, and ethicists who assess risk and fairness.

His description of Mount Sinai’s governance architecture is instructive: AI applications are grouped into domains — clinical care, operations, workforce, research, and students — and supported by an assurance function and a REP committee. This structure enables domain-specific workflows while maintaining centralized oversight.

On prioritization, Mount Sinai requires submissions of ideas from across the health system and aligns them against a 12–24 month set of strategic priorities. Projects are evaluated not only for financial return but for workforce impact, patient experience, and other non-monetary dimensions. This “360-degree” ROI approach ensures that success metrics include provider satisfaction, patient outcomes, and adherence to ethical milestones — with remediation plans if KPIs fall short.

Where Next: Multimodal Integration and Augmentation

Dr. Nadkarni expects the next wave to be multimodal AI – systems that combine text, voice, image, and sensor data. Medicine is inherently multimodal — clinicians integrate visual inspection, conversation, and subtle behavioral cues when making judgments — and AI will need to mirror that complexity. He cautioned that progress will be incremental and that augmentation, not replacement, is the likely near-term path. “In the short term… it’s about augmentation rather than replacement,” he said, underscoring both the potential and the limitations of current systems.

In addition, leaders should prioritize transparency with patients and staff, obtain informed consent, clearly explain how AI-generated notes and alerts are used, and provide clinicians straightforward ways to review and correct machine outputs. Transparency builds trust and smooths adoption. Health systems must invest in continuous monitoring and learning loops so models improve over time and minimize drift or unexpected bias. Training programs to help clinicians interpret AI outputs and to act on recommendations will accelerate practical adoption. These operational investments — governance, monitoring, education, and workflow redesign — are essential complements to any technical innovation.

Practical Implications for Clinicians and Health Leaders

For clinicians and executives contemplating AI adoption, the episode offers several actionable takeaways. First, focus on problems that buy time or reduce friction — documentation automation and early warning systems are tangible, high-impact examples. Second, build multidisciplinary teams and governance processes before scaling. Third, adopt multidimensional ROI frameworks to capture patient and workforce effects, not just cost savings. Fourth, prioritize transparency and training so clinicians understand AI outputs and patients are informed about how data are used. Finally, monitor models continuously to detect drift, bias, and unintended consequences.

Dr. Nadkarni’s mantra — that AI is an “arbitrage of knowledge for time” — reframes technology as a time-saving, decision-enabling tool rather than a pure technical curiosity. By combining clinical insight, disciplined governance, and a patient-centered ROI lens, organizations can harness AI to shift care from reactive to proactive — while safeguarding trust and equity at scale.

AI in Healthcare is an Arbitrage of Knowledge for Time

Season 6: Episode #181

Podcast with Dr. Girish N. Nadkarni, Chief AI Officer, Mount Sinai Health System

AI in Healthcare is an Arbitrage of Knowledge for Time

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In this episode, Dr. Girish N. Nadkarni, Chief AI Officer at Mount Sinai Health System, discusses his background as a physician-technologist and his vision for AI in healthcare as a tool that augments rather than replaces clinicians.

Dr. Nadkarni shares insights on how AI is reshaping healthcare. He describes AI as an ‘arbitrage of knowledge for time,’ enabling physicians to spend less time on administrative work and more time with patients. He also shares real-world examples including ambient AI scribes that eliminate manual note-taking and predictive models that detect patient deterioration hours before it occurs, especially in critical care units such as the NICU. Dr. Nadkarni distinguishes predictive AI’s deterministic approach from generative AI’s flexible, non-linear potential, emphasizing the need for governance, ethics, and trust in deploying both. He outlines Mount Sinai’s cross-functional framework—spanning care, operations, workforce, and research—supported by an assurance lab to monitor bias and safety.

Dr. Nadkarni highlights current AI applications that save physicians time and enable proactive care, while predicting future developments will include multimodal integration of text, voice, images, and video to better reflect clinical decision-making processes. Take a listen.

Video Podcast and Extracts

About Our Guest

Dr. Girish N. Nadkarni is the Fishberg Professor of Medicine, Chair of the Windreich Department of Artificial Intelligence and Human Health, and Chief AI Officer of the Mount Sinai Health System. A physician-scientist and clinical informaticist, he leads transformative AI research in cardiovascular and kidney care, including the first FDA-approved AI-bioprognostic for kidney disease. He has over 460 publications, 40,000 citations, and an h-index of 93. As PI on ~$40M in grants and contracts, he also co-founded multiple FDA-cleared AI startups. Dr. Nadkarni serves nationally in AI leadership and mentors future faculty leaders, earning numerous awards for research and innovation.


Rohit: Hi Girish. Welcome to The Big Unlock podcast. Really wonderful to have you here.

Girish: Hi Rohit, hi Ritu. Thanks for having me. It’s a pleasure.

Ritu: Welcome, Dr. Girish. We have a lot of episodes—175 and counting. Listeners are always in for a treat, and they enjoy hearing new perspectives on AI. Every physician has such different thoughts about AI, how they got here, and what they think future trends will be. So, I’m looking forward to an engaging and interesting discussion. Welcome once again.

Rohit: Thank you. I’m Rohit Mahajan, Managing Partner and CEO at Damo Consulting and BigRio.

Ritu: I’m Ritu M. Uberoy, currently based in Gurugram, India. Also, a Managing Partner at BigRio and Damo Consulting, and co-host of The Big Unlock podcast with Rohit. Looking forward to our discussion today. We’d love to start with your introduction.

Girish: Thanks, Ritu and Rohit. My name is Girish Nadkarni. I am the Chair of the Windreich Department of Artificial Intelligence at the Mount Sinai Health System. The department is the first of its kind in the country, established within a health system and medical school.

I’m also the Director of the Hasso Plattner Institute for Digital Health at Mount Sinai. Those are my academic roles. In addition, I serve as the Chief AI Officer for the health system. Clinically, I’m an internist and nephrologist, and I still actively see patients about 25% of my time—both in outpatient settings and on the clinical floors.

Most of my time is spent doing research, but more importantly, translating, deploying, and scaling that research into clinical care and operations.

I grew up in Bombay, India, which some of you may know is one of the largest cities in the country. I live in New York City now, but the scale of Bombay—or Mumbai—can put New York City to shame, just in terms of the number of people.

I went to medical school in India. From a young age, I was interested in tech and computer science. As you both know, in India you typically either go into engineering or medicine. My parents made it clear: you’re either a doctor or an engineer—or you’re a failure. Both of my parents were doctors, and although I cleared the engineering entrance exam, I was drawn to medicine.

Medicine is a noble profession. What’s more noble than helping and healing people when they’re most vulnerable? More importantly, I was interested in prevention—helping people before they became that sick.

During medical school in India, I always wanted to further my training in the United States because it has led the world in innovation at the intersection of medicine and technology. I came to the U.S., completed a master’s degree and postdoctoral fellowship at Johns Hopkins, and since 2009 I’ve been in New York City.

I did my residency, fellowship, research, operational training, and faculty roles all at Mount Sinai. The health system is unique because it combines a medical school and a health system, which creates a free-flowing exchange between academic discoveries and clinical operations. Research can be translated and scaled across the system, while clinical practice inspires new basic research questions.

I feel fortunate to be in this role. Healthcare is a field where change is often imposed externally—by policies or new technology—but meaningful change must also come from within. If clinicians broadly—physicians, nurses, and other health professionals—become true evangelists for responsible tech, we can create transformative change in healthcare like never before.

Ritu: That’s a great introduction. Thank you so much, Girish. I’m really curious—right now with AI and the rapid pace of change, especially with LLMs, we’re hearing about a lot of physicians and clinicians getting into tech. But your interest in tech predated all of this. Tell us a little bit about that—how you felt back then versus now.

Today, people feel that AI is so enabling. It has democratized access to technology and made it easier for non-tech people, especially clinicians and physicians, to prototype and build things they couldn’t before. Do you feel the same way? Do you think the pace of change has been like light years’ worth?

Girish: I’ve been in this field for the last 15 years, and my interest in tech has always been for medicine’s sake. Technology is one way you can scale impact in ways a single physician—or even a single healthcare system—cannot. Tech can touch millions of lives at scale, which is what drew me to it.

The idea is to take what we know from medicine and codify it into a knowledge base that can then scale across demographics, populations, countries—even globally. That’s the promise of tech.

Yes, things have gotten easier in terms of building and prototyping because of large language models. If you think about what LLMs are, they’re essentially encoded human knowledge at scale. They’ve read all of human knowledge, compressed it, and made it possible to converse with and ask the right questions to get back knowledge at scale.

This democratizes access. Now, if a physician has an idea, they don’t need to rely on a lengthy process to prototype it. They can bring their idea to life as an app or a product and test how it works.

But this also introduces unique challenges. Let me start with a couple of assumptions I hope we all agree on. First, healthcare is an industry where trust is paramount—trust between provider and patient, and trust between the system and the broader social and cultural environment it operates in. We must safeguard that trust.

Second, while scale is useful, it has a flip side. If goodness can scale, badness can scale too. A useful, effective product can scale—but so can mistakes or bias. That’s why it’s essential to be rigorous, responsible, and trustworthy in healthcare. This is a trust-sensitive, patient-centric industry, and we cannot allow mistakes or bias to scale unchecked.

So yes, prototyping and scaling make sense—but they must be backed by rigor, good governance, and solid evidence.

Ritu: Great. That’s what we’ve been hearing across the board—it comes with its own baggage, and you have to be really careful to, as you said, have rigor, responsibility, and trust, which are paramount. Great answer, thank you. Rohit, would you like to ask a question?

Rohit: Yeah, Girish. Could you tell us a little more about your AI journey, or share examples you’ve seen that have positively impacted patients—something we could talk about today?

Girish: Oh, absolutely. I can talk about the broader AI landscape in healthcare right now. I think healthcare is at a transition point. The U.S. healthcare system costs a lot of money and is focused predominantly on sick care rather than healthcare. We wait for people to get sick, then we treat the sickness. The financial incentives are also aligned that way—and that needs to change.

The promise of AI, in my view, is that it’s an “arbitrage of knowledge for time.” What I mean is that because knowledge is compressed and encoded, you can use it to buy time for making decisions.

A great example in healthcare is ambient scribes. As a physician, suppose I have a 20-minute patient visit. In practice, I spend 10 minutes talking to and examining the patient, then another 10 minutes typing up my note. Alternatively, I could spend the full 20 minutes with the patient—but then I’d have to go home after putting my kids to bed and finish my notes.

Ambient AI scribes flip that paradigm. During a natural clinical conversation with a patient, you don’t have to type into the computer. The entire interaction is transcribed into a structured note. All you have to do is review it for accuracy and sign off. What used to take 10 minutes per patient now takes 30 seconds. That’s what I mean by arbitraging knowledge for time—you gain time back with every patient and avoid doing data entry after hours.

Another example: imagine if you knew a patient was going to deteriorate in the hospital one or two hours before it happened. That time would allow you to make a life-saving intervention. That’s another way AI arbitrages knowledge for time—by shifting care from reactive to proactive.

We developed a deterioration model that predicts if a patient is going to get sick an hour in advance. It allows clinicians to intervene, maybe give IV fluids or switch antibiotics, before the patient worsens. That model is already in production.

A second example, very close to my heart, is in the neonatal intensive care unit, where premature babies are often the sickest patients in the hospital. Using vision AI—similar to the technology in self-driving cars—we can continuously monitor babies and predict an hour in advance if one is going to get sick. That gives care teams time to act and potentially prevent deterioration.

So again, I like to say AI in healthcare is an arbitrage of knowledge for time. It gives providers time to make critical decisions and also gives them back time in their day that would otherwise be lost to data entry and processing tasks.

Ritu: Amazing. This neonatal ICU example is incredible. I can only imagine how many babies’ lives have been positively impacted. That’s a wonderful story—thank you for sharing, Girish.

Rohit: Girish, I think we were talking the other day about traditional AI and the new AI—generative AI and large language models. How do you distinguish between the two in your team? And how do you build teams for AI work, since these tasks often require cross-functional expertise—problem definition, technical skills, and domain knowledge? How do you structure that at your organization?

Girish: That’s a big question, but I’ll try to answer it in parts. AI has been used in medicine for a while now, but most of it has been predictive AI. It’s been, “Given this set of data, what is the probability that something good or bad will happen to the patient in a certain amount of time?”

The difference between that and generative AI is that predictive AI is usually deterministic. If you enter the same set of features, you’ll get the same answer every time—it’s very repeatable. New AI, on the other hand, is much more flexible and non-deterministic. You can get different answers to the same question depending on context.

It’s almost like the left and right sides of the brain. Predictive AI is extremely logical, follows a process, and arrives at an answer. Generative AI is more creative and non-linear. Both have to be governed differently, and the way you evaluate them is also different.

With predictive AI, you focus on making sure it isn’t biased against certain populations, and that when you deploy and monitor it over time there’s no drift—meaning the model doesn’t degrade as the underlying data changes. Generative AI requires a more holistic evaluation. You have to ensure it aligns with a broader set of ethics and values, and put guardrails in place so it doesn’t deviate from them.

We’re setting up what we call an “assurance lab” to monitor both predictive and generative AI in different ways, but with the same underlying goal: AI must be safe, effective, responsible, and ethical.

And for that, you need cross-functional teams. You need someone who understands the clinical problem—that could be a doctor, nurse, medical assistant, or allied professional. Then you need someone who can build AI models at scale, usually an MLOps or AIOps engineer. You also need researchers, because sometimes you need people to think outside the box and explore different solutions. Finally, you need a layer of ethics—people who understand the risks and ensure the work is responsible.

We’ve set up a governance structure that combines all digital and AI applications, divided by domain. There’s an AI care domain focused on clinical care; an AI operations domain for back-office operations, finance, and regulatory; an AI workforce domain for workforce applications; a research domain; and a student domain. All of these are underpinned by the assurance lab and by the REP—Risk, Ethics, and Policy—committee.

Why is this important? Because even if an algorithm is pristine, its application can have issues. For example, you could have an algorithm to predict which patients won’t show up for clinic appointments. But if applied incorrectly, you might cancel the appointments of the very patients who most need care. Often, patients who miss appointments have unmet social needs. The right solution isn’t to cancel on them—it’s to address those needs, like providing transportation or financial support.

So yes, you need cross-functional and multidimensional teams to tackle clinical, operational, or workforce problems. But everything must run through governance to ensure the work is safe, effective, responsible, and ethical.

Rohit: That’s great to know. And when you look at these applications, do you have some kind of framework or success metrics—what people often call return on investment? How do you go about prioritizing projects, especially now that so many physicians are becoming interested and more ideas are coming your way as Chief AI Officer?

Girish: Yes. We have a process where anyone in the health system can submit an AI or digital idea. I work closely with the Chief Digital Transformation Officer, Robbie Freeman, and our Chief Digital Officer, Lisa Stump, on this.

First, as a health system and academic institution, we define a list of clinical and operational priorities for the next 12–24 months. Part of the process is aligning ideas to those priorities. If an idea aligns with strategic priorities, it gets higher prioritization and faster execution.

Second, every idea must go through governance, as I described earlier, to ensure it is safe, effective, ethical, and responsible—not only in development, but also in execution.

Third, we calculate ROI for all priority projects. But this is a multidimensional ROI—it’s not just financial. We also consider workforce impact and patient experience impact. It’s a holistic, 360-degree evaluation.

We also monitor projects over time to ensure they meet predefined milestones. For example, with an ambient AI project, one milestone might be provider satisfaction. How many providers are satisfied with it? We track KPIs, and if a milestone isn’t met, we require an explanation and a remediation plan.

This way, we ensure ROI is not just about finances—it’s about employee experience, broadly defined, and patient experience as well.

Rohit: And one tough problem I’ve seen before—and something the C-suite often struggles with—is where the money comes from. If you’re focused on cost savings, you might say, “We’re going to save costs by becoming more efficient.” That’s one way to look at it. But how do you think about budgeting for AI? Is it longer-term or shorter-term? Any high-level perspective you can share?

Girish: If you align your roadmap—your operational map—with the larger strategic priorities, then you automatically get C-suite buy-in. These are priorities already set by leadership, and we’re just enabling and accelerating them. That also makes it easier because budgets have already been allocated for those priorities.

And honestly, the cost of generating software has gone down significantly. You know this better than me—the cost of coding agents and developing software is far lower than it used to be. So if incentives, strategic priorities, and broader vision are aligned, the more tactical, lower-scale items start to align as well.

Rohit: That’s great to know.

Ritu: So Girish, you mentioned “ambient” a couple of times, and we all know that’s been one of the big success stories across hospitals and health systems. Our listeners always want to hear what’s coming next—straight from our guests. In terms of trends, what do you think will be the next big win for AI? Where is it headed in the next 6–12 months?

Girish: In the next 12 months, I think we’ll see much more multimodal integration, which is especially relevant in medicine. Right now, most AI is text-based. But that’s not how clinical decisions are made. Clinical decisions involve talking to the patient, observing them, noting how they look, how they speak, and even their frame of mind in that moment.

The technology isn’t fully there yet, but I think it will be in the next few years. And I still believe that in the short term—say, the next 10 years—it’s about augmentation rather than replacement. These systems, while powerful, are fragile, and trust is a huge factor. People aren’t ready for a fully autonomous AI doctor.

So I see multimodal integration—combining text, voice, images—becoming more common. We’ll see a push beyond ambient recording, perhaps toward video recording with patient consent, sensors, and more. Broadly, though, I think the shift will be from reactive medicine to proactive medicine, and AI in all its forms will be an enabler of that.

Ritu: Great point. We’ve also been hearing a lot about voice agents and conversational AI, so I think you’ve hit the nail on the head there. Thank you.

Rohit: Thank you, Girish. As we come to the close of the podcast, are there any final thoughts you’d like to share with our listeners?

Girish: I’d just say this: AI is a very impressive technology. For the first time in human history, it’s approaching cognition, which until now was the preserve of humans. We should think of AI as a collaborator, not a replacement—something that helps us become the best version of ourselves.

At the same time, we shouldn’t wear blinders and assume it’s flawless. We need honest assessments, constant monitoring, and recognition of its flaws. There’s hope, and yes, there’s hype, but it should always be tempered by reality and rigor.

Rohit: That’s a great closing thought. Thank you so much, Girish. We really appreciate your time.

Ritu: It was wonderful having you on the show. Thank you for joining us.

Girish: Thank you both. It was a pleasure.

————

Subscribe to our podcast series at www.thebigunlock.com and write us at [email protected]  

Disclaimer: This Q&A has been derived from the podcast transcript and has been edited for readability and clarity.

About the host

Paddy is the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor & Francis, Aug 2020), along with Edward W. Marx. Paddy is also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He is the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He is widely published and has a by-lined column in CIO Magazine and other respected industry publications.

About the Hosts

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has previously also worked with IBM and Wipro. He completed his executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

Ritu M. Uberoy has over twenty-five years of experience in the software and information technology industry in the United States and in India. She established Saviance Technologies in India and has been involved in the delivery of several successful software projects and products to clients in various industry segments.

Ritu completed AI for Health Care: Concepts and Applications from the Harvard T.H. Chan School of Public Health and Applied Generative AI for Digital Transformation from MIT Professional Education. She has successfully taught Gen AI concepts in a classroom setting in Houston and in workshop settings to C-Suite leaders in Boston and Cleveland. She attended HIMSS in March 2024 at Orlando and the Imagination in Action AI Summit at MIT in April 2024. She is also responsible for the GenAI Center of Excellence at BigRio and DigiMTM Digital Maturity Model and Assessment at Damo.

Ritu earned her Bachelor’s degree in Computer Science from Delhi Institute of Technology (now NSIT) and a Master’s degree in Computer Science from Santa Clara University in California. She has participated in the Fellow’s program at The Wharton School, University of Pennsylvania.

About the Legend

Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor &  Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.

AI, Design, and the Future of Operational Workflows in Unlocking Healthcare Efficiency

Season 6: Episode #180

Podcast with Michael Docktor, MD,
Co-founder and CEO of Dock Health

AI, Design, and the Future of Operational Workflows in Unlocking Healthcare Efficiency

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In this episode, Dr. Michael Docktor, Co-founder and CEO at Dock Health, shares his journey from being a pediatric gastroenterologist at Boston Children’s Hospital to building a healthcare technology company. Inspired by his sister’s medical experiences and his family’s design background, Dr. Doctor combined medicine, design, and technology to address inefficiencies in operational workflows, particularly the administrative burdens that weigh heavily on providers and staff.

Dr. Docktor explains how Dock Health was created to serve as a productivity platform for healthcare, filling the gap between electronic health records (EHRs) and the countless administrative tasks not supported by them. By digitizing and streamlining processes like referrals, patient intake, and care coordination—often still managed through faxes, emails, and spreadsheets—Dock Health aims to reduce redundancy, improve visibility, and enhance the overall user experience for healthcare organizations of all sizes.

The conversation also focuses on the role of AI and automation in transforming healthcare operations. Dr. Docktor highlights Dock Health’s “AI‑first” approach, incorporating generative AI and agentic models to automate routine tasks while keeping humans in the loop for oversight. He envisions a near future where administrative inefficiencies are largely eliminated, giving clinicians more time with patients. Dr. Docktor also describes AI as the “big unlock” that could massively reduce the trillions wasted annually in healthcare administration, making care more efficient, accessible, and patient‑centered. Take a listen.

Show Notes

01:14What interests you in the healthcare industry segment to become the CIO of a hospital system?
02:47How long have you been in the leadership position at UMC, where is it located, and what kind of population does it serve?
03:35You have done a lot of work from technology perspective to support the business needs of the hospital. You've done over 200 applications and transformed the EMR system. Would you like to share with the audience the thought process that drove those changes and what were some of those changes?
07:47What do you think about your digital transformation efforts? If you could describe a few of them which have had impact on the patient population.
08:30Please describe in your own, you know, way that what is digital transformation for provider systems such as yours? Where do you see it going? Some of the challenges that you might have faced and how did it actually end up impacting patients?
11:24 How did you manage to change the mindset of the people? How did they manage to change themselves? To adapt to this new world where technology, especially with AI and GenAI and other new technologies which are coming our way, how do you change mindsets and change behaviors and change culture over there?
13:00Would you like to provide one example of how the technologies which you were implementing, and you continue to be implementing in your hospital system are accessible and usable by a variety of users, including within the hospital and outside the hospital.
16:28How do you innovate? Do you involve external parties? Do you have some kind of a, you know, innovation focus department? Or is it part and parcel of everybody's, you know, kind of like daily life?
19:24What are your thoughts on new technologies, especially Gen AI? Have you been experimenting with any predictive analytics or large language models? What would be your advice or thoughts to any other healthcare leaders on how to go about this journey of exploration?
22:15Standing here now and looking back, if you were able to go back and change one or two things, what would you like to do differently or have done differently?

Video Podcast and Extracts

About Our Guest

Michael Docktor, MD, is the co-founder and CEO of Dock Health, the first AI-powered productivity platform purpose-built to solve healthcare’s operational challenges — from referral management to task automation and workflow orchestration. A practicing pediatric gastroenterologist at Boston Children’s Hospital, Docktor previously served as the hospital’s clinical director of innovation and director of clinical mobile solutions.

With nearly two decades of experience at the intersection of clinical care and digital transformation, he is focused on bringing clarity, accountability, and efficiency to the work behind care.


Q: Hi, Dr. Michael Docktor, welcome to our Big Unlock podcast. We are really happy to have you as a guest on our show. Uh, it’s on our sixth season now, and, uh, we are looking forward to this conversation. I’m sure we’ll have a very engaging and interesting conversation about dog health, about healthcare in general, and the new trends about AI and all the buzzwords that people want to hear. Welcome to our show — we’d like to start with introductions. Happy to have you give your introduction. Thank you.

Michael: Yeah, thank you so much for having me. Yeah, I’m Michael Docktor, co-founder and CEO of Dock Health. I’m an ologist by trade. I am now on this, uh, healthcare venture outside of Boston Children’s Hospital where I started my GI career.

I was a busy clinician working on the clinical side as well as in innovation and informatics, and found that we had wonderful tools in the world outside of healthcare and struggled with my own challenges around managing all the tasks that are part of patient care. I found that I was using task management and project management tools that were not built for healthcare.

I scratched my head and wondered why we don’t have these things for healthcare. That was a journey. We started just over five years ago. We spun out Dock Health from Boston Children’s, and we’ve been on a very exciting journey in the world outside the academic walls since then.

It’s been fun. I’m excited to talk to you more about, uh, what we’re doing.

Q Great. That’s a great introduction. Thank you for letting our listeners know. We usually like to start with how you came into healthcare because everyone has an interesting story about what inspired them to become a physician.

For you, it’s particularly interesting because you’ve created this interface between design, technology, and healthcare — and you went beyond just visualizing what you wanted to do or asking why somebody doesn’t fix it, to actually building it yourself. I’d love to hear more about how you came into medicine and then into technology.

Michael: I could probably spend the entire podcast on this question. Obviously, my last name is Doctor, so there was some planting occurring there, and there’s something to be said for that.

One of my earliest memories was wanting to grow up to be a doctor. My younger sister had some GI issues when we were young, and I became very close with her gastroenterologist. I followed her on her journey and, unbeknownst to me, ended up following one of my mentors and was inspired to do the work for other children the way my sister was cared for. That was the initial inspiration.

You mentioned design. That’s interesting because my mother is an interior designer, my father is a dentist who specialized in aesthetics, and design — how things look, feel, and work — has always been part of my DNA. It was an amazing journey to go from being a traditional doctor in pediatric gastroenterology to discovering the importance of user experience and user interface.

Then the iPhone came out, then the iPad, and that really started me on my journey of exploring app development and software, and wondering why we didn’t use these wonderful devices in our pockets the way we should. That journey started more than 10 years ago and has led me to this perfect intersection of healthcare, design, and informatics, creating better experiences for patients and providers.

There’s a lot to unpack there, but people ask me if I would do it differently if I had the chance to do it all over — and absolutely not. I’m doing exactly what I want to be doing right now.

Q: Thank you for sharing that. That gives us so much perspective into how you came into this field, the influence of your parents, and how everyone around you inspired you to do this. That’s really interesting.

That leads us into how you built Dock Health. Tell us some examples of how you saw this becoming transformational in actual implementations with clients. When you built the tool, did you visualize exactly what it would do? Did it go beyond what you thought it would achieve in a healthcare setting? We’d love to hear more about that.

Michael: We’re far beyond where I ever thought we’d be when we first started this journey. That’s the exciting part. Fundamentally, we have such an administrative and operational challenge in healthcare. I saw it firsthand as a busy clinician struggling to manage all the clinically adjacent work that had to be done for my patients.

For example, I might have a patient with Crohn’s disease who needs to go to an infusion center. There are all these downstream tasks and administrative steps that need to be done by a team of people. We didn’t have assistants to do that, and the electronic health record wasn’t built for it.

A quarter of the $5 trillion spent in healthcare goes to administrative and operational challenges, and there really are no tools built for that. We rely on paper checklists, email, faxes, and spreadsheets to manage all the work happening outside the electronic health record.

For me, the realization was that I was using wonderful project management and task management tools to run software projects in my innovation and informatics roles—and yet nothing like that existed in healthcare. Patients, in many ways, are projects. There are tasks that form the essence of care, and they need to be tackled, managed, and collaborated on, with visibility and accountability across teams. That didn’t exist.

What we are now doing is serving as that productivity platform for healthcare, one that sits alongside the electronic health record in synergy, helping manage all the administrative and operational tasks of patient care in ways the EHR wasn’t designed for.

Some examples would be managing patient intake and all the processes associated with it. Referrals, inbound and outbound, with all the paperwork, eligibility checks, and faxes—those workflows are still incredibly manual. Referrals are a great example: 80% of referrals that come into major academic medical centers are still arriving by fax, despite the fact that they’re using Epic, a wonderful electronic health record.

These processes are still incredibly laborious, take too long, and are inefficient. Patient care suffers along the way. There’s a gigantic bottleneck around the administrative and operational work that moves patients through their journeys, and that’s what we’re focused on fixing.

Q: This is what we hear from a lot of our clients and other CIOs and C-suite leaders who come to our podcast—that this is one major problem with healthcare. It’s siloed, and the processes are really stuck in the dark ages.

We were talking to somebody from Athena, and they said they had an 800-person offshore center in India just to screen faxes. When a fax came in, one person looked at it to see if it was a pizza order or a referral. It sounds unbelievable in this day and age, but that’s how it works. I’m amazed to hear this from you as well. It’s remarkable.

Michael: Yeah. In fact, Athena is a partner of ours, and we’re working on referral management. It’s an incredibly antiquated process where everyone loses visibility. The amount of manual labor required to process these things is shocking in this day and age, when they can be handled through process automation, AI, and agents.

Q: Exactly. You’re talking about agentic, we’re talking about voice agents, and yet we’re still dealing with faxes. That’s really interesting to know.

Michael: There is reason to be hopeful. Healthcare is always many decades behind, but the adoption of AI is progressing more rapidly than I’ve seen any technology adopted in healthcare. There’s reason for hope.

Q: That leads into my next question, but before we get there, you mentioned Dock Health as a productivity platform. That’s what it does for doctors, clinicians, and patients. But when we talk to our doctors, clients, and health systems, the one word that always comes up is complexity. They deal with so many different systems and have to learn something new each time.

Where does Dock Health fit in? Is it another system they have to manage, or does it help reduce that burden?

Michael: Yeah, it’s all about reducing the burden and improving the user experience. That’s been fundamental to our belief system since the founding of the company.

First and foremost, we’re trying to become the productivity platform and the hub that handles the administrative and operational work. Instead of being “another system,” we’re often replacing spreadsheets, paper checklists, emails, and faxes—the ways we’ve traditionally managed the 50% or more of administrative and operational tasks required for patient care.

The EHR is great for clinical work, billing, prescribing, and scheduling, but so much happens downstream that isn’t covered. I’d argue we are creating the hub for that. Just as the EHR is the clinical hub, Dock Health serves as the operational hub. Together, it’s really one plus one equals three.

We’re also aiming to be much more consumer-like in our approach. Our tool can onboard a customer in 30 minutes. We offer a free trial, and for small organizations that want to get up and running, they can start using it right away—just like downloading an app. It’s lightweight, highly configurable for end users, and designed with a strong focus on user experience.

The real challenge is that clinicians don’t want another tool. They’re busy and need to spend their time in the EHR. Our core users are often the super users: front office staff, back office teams, operational leaders, and administrative staff who leverage our tool every day.

The important piece is that we connect to the electronic health record and provide visibility for clinicians. If they’re interested, they can see where a patient is in their journey or where a process stands, but they don’t have to be in our system all day, checking tasks or learning another workflow.

The intent is to provide that operational hub for administrative and support staff—the essential members of the care team—while clinicians continue their work in the EHR and often drive tasks into our system through their orders and actions there.

Q: Is the integration with the EHRs native, like with Epic, Cerner, and the big ones?

Michael: Yeah. We’re on the marketplace with a number of the top EHRs, including Epic and Cerner. We’re also working with Mayo Clinic, their Mayo Clinic Platform, and their Deploy platform.

The other thing I’d mention is that many organizations use our tools without being integrated with the electronic health record. That’s often because they’re smaller practices—mental health, concierge care, or primary care—that simply need a hub to handle administrative and operational work and collaborate as a team.

We spend a lot of time helping organizations define their processes, and those processes can then live in Dock, where they can be collaborated on and turned into operational best practices. That’s something that often doesn’t happen in traditional healthcare organizations, and our tool is valuable even when it’s not connected to an EHR.

Of course, the real value comes when we integrate with systems—EHRs, CRMs, patient engagement tools—and serve as the hub while automating as many tasks as possible. That’s when the flywheel starts turning, and organizations begin to feel the benefits of automation and work reduction. It ultimately moves the needle in a measurable way.

Q: So, you’re saying if there’s an integration with the EHR, then it’s end-to-end and people can see a complete view of what’s happening. But even without the EHR, because it helps with workflow management, it’s valuable for practices?

Michael: It’s just like every other industry. They have Asana, JIRA, Trello—all these tools where a lot of the real work gets done. That provides value in itself by giving a clear view into where the patient is in their journey and what process they’re following.

When we integrate with an EHR or other systems, we can then automate those workflows. For example, when a fax comes in, we can launch a workflow for a new patient referral. When a lab order is placed, we can launch a workflow for follow-up. Or when a patient has a procedure, we can launch a process for their downstream follow-up.

Q: That leads into the next question, which is your learning journey with AI. What advice do you have for our listeners about where AI is headed? And with voice agents and agentic tech being buzzwords, where do you see Dock Health going? Are you also looking at implementing voice agents?

Michael: AI is incredibly exciting. I’ve put it out there that we’re an AI-first company. We’ve been thinking about this for a while, and we already have what we call Dock Intelligence in production with customers. We started with the basics, using foundational models and generative AI to process large troves of data.

Now, we can summarize all the work being done for a patient and create a snapshot for the end user—showing all tasks, workflows, patient context, and even clinical context if available. That gives a quick overview of what’s happening. Users can edit that snapshot if needed, or generate a note that writes back to the EHR to keep the operational and clinical record in sync.

That’s the first step in our AI journey. From there, we realized tasks bundle into workflows, workflows can be automated, and now we’re starting to farm out those tasks to agents and AI. For example, a voice agent could follow up with a patient to confirm a referral or review lab results. We’re actively pursuing that, as well as leveraging AI to extract data from faxes to automate referral processes.

AI is the big unlock. In the next three to five years, I believe most administrative and operational tasks will be handled by automation and AI agents orchestrating together. These agents need rails to run on and structure to guide them, and end users must remain in the loop to provide oversight and visibility. But the lion’s share of this work will be handled by agents—and we’re building that future right now.

Q: Are you aligning specifically with any particular LLM or provider, or are you going to be completely agnostic?

Michael: I’d like to think we’ll be agnostic. We’re doing plenty of building on some of the foundational models ourselves, and we’re partnering where we can with great tools. For example, with voice agents, we’re not necessarily building them ourselves—there are excellent options out there. What we are doing is building our own homegrown AI agents that can manage processes and facilitate handoffs from task to task.

Our approach has always been to recognize that there’s a wonderful ecosystem out there. We want to be the hub that connects to the best-of-breed systems—whether that’s Epic as an EHR, Salesforce as a CRM, or other tools we can leverage to create a healthy ecosystem. That’s what we’re pursuing.

Q: I wanted to ask a question about that because with the LLMs, one of the main problems is the hallucinations or the repeatability or the trust factor there. So I saw that Dock is HITRUST certified. So, I just wanted to ask, what are your views on that? Because in terms of using generative AI when we talk to our clients, uh, for implementations on LLMs, or they’re more comfortable certainly with the administrative tasks, but even with the administrative tasks there’s always the question of what are the guardrails you put around that and how do you make sure that the results that you are seeing or you are displaying on Doc Health, you know, stay within that, those bounds of accuracy. Whathat are your thoughts around that?

Michael: AI is incredibly exciting—it’s moving at the speed of light, and everyone wants to benefit from it. I do think administrative and operational areas of healthcare are lower-hanging fruit and far less risky. We’re not yet in a place where we can reliably use AI for absolute clinical decision support and autonomy, though I believe we’ll get there in the not-too-distant future.

For now, the clunky and manual administrative work is ripe for AI. Still, we need to be mindful of potential hallucinations. In our experience so far, we haven’t seen issues, but we’ve put safeguards in place. That means keeping a human in the loop to ensure outputs are appropriate and relevant. We also give users the ability to edit results before they’re sent—whether it’s a summary being emailed to a colleague or written back into the EHR as a clinical note.

It’s essential to show your work. If we’re pulling data from various sources, we show those sources. We keep users in the loop, give them control to review and edit, and maintain tight feedback loops to catch and address anything off.

So far, even foundational LLMs have been surprisingly strong in our relatively narrow use cases. The real challenges will come as we move toward higher-risk clinical decision support—but I’m confident we’ll get there quickly.

Q: It’s interesting you mentioned humans in the loop and the fact that people can review or edit what’s being generated. But with agents, one of the key defining characteristics is autonomy—they can make API calls, send emails, even browse the web to find and act on information. How do you think about that level of control being handed over?

Michael: I think it’s all about balance. The value of task automation and workflow automation is clear. For us, one of our strengths is providing a user interface where the end user can actually see where a process is in its journey.

We’re working on features like showing confidence levels or confidence intervals for data extracted—for example, from a fax. That way, we not only show our work but also give transparency into how accurate that extraction might be. Using our interface, which breaks workflows into tasks, we can show exactly where a process stands. If we believe human involvement is needed, we assign a task and call someone in to review.

Even in the agentic future—which is already upon us and actively being built and tested—we see ways to keep humans in the loop. Operating entirely in a vacuum is risky. Part of my mantra, coming from clinical practice, is that I lacked visibility and accountability in the work being done on behalf of my patients, lost in a black hole of faxes and emails. It’s important to show where the patient is in their journey, where the process stands, whether an agent is handling it or automation is moving data between systems. Giving people visibility and the ability to drill down is critical.

Q: That’s an interesting viewpoint. You mentioned the front and back office and clinicians, but I didn’t realize patients might also have visibility into the system.

Michael: That’s certainly the vision for the future. Right now, our solution focuses on creating visibility and accountability for the care team—clinical and operational staff. But ultimately, the patient is part of the care team too. I would love to see a future where patients are assigned tasks and the rest of the care team has visibility into their progress. I think that’s inevitable. For now, we’re focused on giving the traditional care team the tools they need, but over time, I see patients and their home-based care team being part of that ecosystem.

Q: So I think we are almost at the end of the podcast. We would like to conclude by asking you what you think, maybe give a horizon of like a year and then maybe a five-year horizon. What do you think the top trends that are going to be in AI, and particularly for you at Dock Health? What are the three things that you are really keeping close tabs on and you feel that it’s going to really impact your product and be very transformational.

Michael: It’s tough to predict because AI is moving so fast. Moore’s Law doesn’t apply anymore—the doubling is happening every few months. Everything right now is AI, and “agentic” is the word of the day. I’ve even heard “ambient agents.” We see our role as orchestrating workflows where agents will carry out the majority of tasks.

When we started Dock Health, I imagined a day when it would be smart enough to handle processes automatically. AI has accelerated that roadmap by five to ten years, and the pace keeps shrinking. I truly believe that in the next five years, when healthcare spending in the U.S. reaches $10 trillion, the $2.2 trillion spent on administrative and operational costs may actually shrink because of operational efficiencies unlocked by AI.

We want to give care teams superpowers. Administrative and operational staff deserve better tools to do their work. Just as ambient scribes are now relieving clinicians from documentation, I believe AI will do the same for the administrative and operational burdens in healthcare. Within three to five years, I expect most of that work will be automated. Humans will still play a role, but much of it will feel like it just happens—almost magically.

If you zoom out five years from now, it will look like magic. But by then it will feel obvious. And that excites me, because at the end of the day, patients, our economy, and the world need more efficient care. The fact that we waste a trillion dollars a year on administrative tasks is shameful. Patients are asked to take on too much, like reminding us about referrals or tracking down lab results. These things happen because we’re human and don’t scale well. But now we have incredible tools at our fingertips, and I believe the next few years will be the most exciting time healthcare has ever experienced.

If we zoom out five years from now, it’s going to look like magic—but by then it will feel obvious. I’m excited for that future because, at the end of the day, patients, our economy, and our world need more efficient care. The fact that we waste a trillion dollars a year on administrative and operational tasks is shameful.

Too much of the burden falls on patients. Physicians and care teams often say, “Call me if you don’t get your referral in a couple of days,” or, as I saw with my own mom recently, patients are left chasing down lab results. These things happen because we’re human and we don’t scale well.

Now, we have incredible tools at our fingertips. That’s why I believe the coming years will be the most exciting time in healthcare that I’ve ever experienced—and likely the most exciting time the world has ever seen. Healthcare is primed for transformation and opportunity.

Q: Thank you for being with us on our podcast. It was a wonderful conversation, and we look forward to sharing your vision for the future with our listeners.

Michael: Thanks so much.

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Subscribe to our podcast series at www.thebigunlock.com and write us at [email protected]  

Disclaimer: This Q&A has been derived from the podcast transcript and has been edited for readability and clarity.

About the host

Paddy is the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor & Francis, Aug 2020), along with Edward W. Marx. Paddy is also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He is the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He is widely published and has a by-lined column in CIO Magazine and other respected industry publications.

About the Host

Ritu M. Uberoy has over twenty-five years of experience in the software and information technology industry in the United States and in India. She established Saviance Technologies in India and has been involved in the delivery of several successful software projects and products to clients in various industry segments.

Ritu completed AI for Health Care: Concepts and Applications from the Harvard T.H. Chan School of Public Health and Applied Generative AI for Digital Transformation from MIT Professional Education. She has successfully taught Gen AI concepts in a classroom setting in Houston and in workshop settings to C-Suite leaders in Boston and Cleveland. She attended HIMSS in March 2024 at Orlando and the Imagination in Action AI Summit at MIT in April 2024. She is also responsible for the GenAI Center of Excellence at BigRio and DigiMTM Digital Maturity Model and Assessment at Damo.

Ritu earned her Bachelor’s degree in Computer Science from Delhi Institute of Technology (now NSIT) and a Master’s degree in Computer Science from Santa Clara University in California. She has participated in the Fellow’s program at The Wharton School, University of Pennsylvania.

About the Host

Rohit Mahajan is an entrepreneur and a leader in the information technology and software industry. His focus lies in the field of artificial intelligence and digital transformation. He has also written a book on Quantum Care, A Deep Dive into AI for Health Delivery and Research that has been published and has been trending #1 in several categories on Amazon.

Rohit is skilled in business and IT  strategy, M&A, Sales & Marketing and Global Delivery. He holds a bachelor’s degree in Electronics and Communications Engineering, is a  Wharton School Fellow and a graduate from the Harvard Business School. 

Rohit is the CEO of Damo, Managing Partner and CEO of BigRio, the President at Citadel Discovery, Advisor at CarTwin, Managing Partner at C2R Tech, and Founder at BetterLungs. He has previously also worked with IBM and Wipro. He completed his executive education programs in AI in Business and Healthcare from MIT Sloan, MIT CSAIL and Harvard School of Public Health. He has completed  the Global Healthcare Leaders Program from Harvard Medical School.

About the Legend

Paddy was the co-author of Healthcare Digital Transformation – How Consumerism, Technology and Pandemic are Accelerating the Future (Taylor &  Francis, Aug 2020), along with Edward W. Marx. Paddy was also the author of the best-selling book The Big Unlock – Harnessing Data and Growing Digital Health Businesses in a Value-based Care Era (Archway Publishing, 2017). He was the host of the highly subscribed The Big Unlock podcast on digital transformation in healthcare featuring C-level executives from the healthcare and technology sectors. He was widely published and had a by-lined column in CIO Magazine and other respected industry publications.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation

The Healthcare Digital Transformation Leader

Stay informed on the latest in digital health innovation and digital transformation.